8-Fluoro-N-2-isobutyryl-2′-deoxyguanosine: Synthesis and Reactivity
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چکیده
منابع مشابه
Synthesis and properties of oligonucleotides containing 8-bromo-2'-deoxyguanosine.
The preparation of oligonucleotides containing 8-bromo-2'-deoxyguanosine is described. Substitution of G by 8-bromoguanine on an alternating CG decamer stabilizes the Z-form in such a way that the B-form was not observed. Melting temperatures showed that duplexes in which 8-bromo-2'-deoxyguanosine paired with natural bases were much less stable.
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The mol-ecule of the title compound, C(15)H(13)FN(2)O(2), exists in a trans configuration with respect to the methyl-idene unit. The two benzene rings form a dihedral angle of of 64.7 (2)°. In the crystal, mol-ecules are linked through N-H⋯O hydrogen bonds into chains propagating along the c axis.
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متن کاملEnzymatic synthesis of 8-vinyl- and 8-styryl-2'-deoxyguanosine modified DNA--novel fluorescent molecular probes.
Fluorescent analogs of the natural nucleobases are widely used as molecular probes for investigating DNA hybridization and topology. In this study the guanosine analogs 8-vinyl- and 8-styryl-2'-deoxyguanosine were synthesized and converted into the corresponding 5'-triphosphates. These C8 modified nucleotides were processed by various DNA polymerases to create fluorescent DNA. Whereas the 8-sty...
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ژورنال
عنوان ژورنال: Molbank
سال: 2020
ISSN: 1422-8599
DOI: 10.3390/m1119